Manageable dosing and administration
TRISENOX
® (arsenic trioxide) injection offers manageable dosing and administration schedules
that are sensitive to the needs of patients.
Unlike many cancer treatments, TRISENOX does not require that you take medications in preparation
for TRISENOX therapy. TRISENOX is administered intravenously (through an IV), usually over 1 to 2
hours. You will be in the office or clinic for about 2 to 3 hours for each treatment, including
about 1 hour for pre- and post-treatment examinations. If you experience certain side effects,
such as flushing or decreased blood pressure, the infusion may be slowed, and it may take as long
as 4 hours to complete.
In many cases, TRISENOX can be administered on an outpatient basis. If you are being treated as
an outpatient, you can drive yourself to treatment. If you have a particularly long drive, however,
you might find you are tired after treatment. As a precaution, it is a good idea to let your family
or friends know you might need their help to get to and from the treatment center.
Your doctor or nurse will tell you how often and for how long you will receive TRISENOX.
>> Click here for frequently asked questions about therapy with TRISENOX.
Serious adverse events, grade 3 or 4, were common. Those events attributable to TRISENOX in the
Phase 2 study of 40 patients with refractory or relapsed APL included APL differentiation syndrome
(n = 3), hyperleukocytosis (n = 3), QTc interval prolongation (n = 16), atrial dysrhythmias (n = 2),
hyperglycemia (n = 2), and torsades de pointes (n = 1).